Multivitamin supplements are effective and inexpensive agents to lower homocysteine levels.

Such "therapy" effectively consists of recommending a multivitamin-mineral supplement with somewhat higher-than-daily-value amounts of several of the B vitamins (pyridoxine hydrochloride [B6], cyanocobalamin [B12], and folic acid). Therapy with, for example, 25 mg of B6, 100 μg of B12, and 400 μg of folic acid is simply obtained in a high "potency" (no-iron) multivitamin that can be bought in the United States for as little as $0.10 a day. Such supplements usually also contain several other nutrients important in homocysteine metabolism (eg, zinc, which is a factor in the betainehomocysteine–lowering pathway).